The Explore, Connect, Conceptualize and Hypothesize are four cognitive functions implemented in our tool to help you navigate the medical literature. A researcher can use them in any order and can even submit multiple search queries simultaneously. The functionality offered with each of the tabs is described below.
Explore: Search functionality in this tab allows you to type and choose a medical term of interest, to retrieve knowledge-facts associated with the term. Explore allows you to learn about the “what-is” around a term or concept. The explore tab presents results from navigating the literature to provide a list of terms that (i) co-occur (mentioned or referenced together often), (ii) share similar facts and properties and (iii) define context around the search term.
Example: If you enter the term “Nexium” and press the “Search” button, facts such as “Nexium interacts with acids”, “Nexium treats Gastroesophageal reflux disease”, etc. will be retrieved along with the list of associated terms (such as Omeprazole, Proton-pump inhibitors), similar terms (such as Esomeprazole, Famotidine, Ranitidine, Antacids, etc.) and context terms (such as Pharmaceutical Preparations, Therapeutic procedure, etc.)
Connect: This search tab allows a researcher to quickly evaluate a “what-if” intuition that two terms may be related in a meaningful way. The artificial intelligence algorithm automatically fills-in-the-blanks to connect the two terms with a sense of semantics and logic. This capability can be used to validate known associations such as Nexium and Heartburn or used to validate hunches such as the potential of treating Ebola virus with Chloroquine (a malarial drug).
Example: For Nexium and Heartburn – ConceptualEyes will present an association as follows: “Nexium is an Esomeprezole. Esomeprezoles affect heartburn.” With Ebola virus and Chloroquine, the result could look like “Ebola virus location_of Epitopes (B lymphocyte). Immunotoxins disrupt Epitopes. Chloroquine negatively_stimulates immunotoxins.
Conceptualize: The Conceptualize tab allows a researcher to quickly organize and investigate the “what-else” around a search term of interest. The results summarize the research activity around the term of interest at a meta-level to augment an individual’s expertise from an adjacent domain
Example: In the Ebola virus example, the results would show that Biologic, Genetic, Pathological, Physiological functions are processes associated with Ebola virus and Ebola virus is also part of a gene or genome, immunologic factor, and a nucleotide sequence.
Hypothesize: The Hypothesize tab is the gateway to ask the “what-could-be” questions. The search tab takes multiple terms of interest as input and does a simulation to predict potential non-obvious associations.
Example: A user can enter terms such as Distal muscle weakness, Gait, Child, Woman and then choose one among many targets (such as Disease, Gene or Drug) that the user is interested in finding a non-obvious connection. If the Disease target is chosen, the output will be a list of potential diseases diagnoses.